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John Diffley, PhD, FRS, FMedSci  🇺🇸 🇬🇧

Principle Investigator


John was born and raised in New York. He obtained his PhD from New York University in 1985, and was a postdoctoral fellow with Bruce Stillman at Cold Spring Harbor Laboratory until 1990. He then started his own research group at the Clare Hall Laboratories (now part of the Francis Crick Institute). He was appointed Associate Research Director of the Francis Crick Institute in 2015.

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Biographical Highlights

Agostina Bertolin, PhD  🇦🇷 🇮🇹


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PhD in Molecular Biology @ the Leloir Institute in Buenos Aires

Agos joined the lab in 2017 to investigate the function of DNA damage checkpoint kinases ATR/Chk1 in human cells, with a specific focus on their impact on replication forks. Prior to this, she was a postdoc in Vanesa Gottifredi's lab, where she studied translesion synthesis DNA polymerases in human cells.

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Berta Canal, PhD  🇪🇸


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PhD in Biomedicine @ University Pompeu Fabra, PRBB, Barcelona

Berta studied cell cycle regulation and environmental stress responses in budding yeast during her PhD with Francesc Posas and Laia de Nadal. She joined the lab in 2019 and was awarded a Marie Skłodowska-Curie Fellowship to study the nature of DNA replication fork stalling and restart. 

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Lucy Drury, PhD  🇬🇧

Laboratory Research Scientist


Lucy joined the lab in 1994. She has led several projects around the mechanism, regulation and misregulation of origin licensing. She also helps to support lab personnel and facilitate the smooth running of the lab.

    Anne Early, PhD  🇬🇧

    Laboratory Research Scientist


    Anne joined the lab in the year 2000, making the switch from developmental biology research to DNA replication. She has been involved with a variety of projects in the lab during that time and helps support the work of other lab members.

      Evelyn Eastwood, PhD 🇬🇧



      PhD in Medical Sciences @ CRUK Cambridge Institute, University of Cambridge


      Evelyn studied the mechanism of piRNA-dependent transcriptional silencing of transposons during her PhD in Greg Hannon's lab at CRUK Cambridge Institute. She joined the lab in January 2024 to work on the initiation of human DNA replication.

        Samson Glaser 🇩🇪

        PhD Student


        BSc & MSc in Biochemistry @ Ludwig Maximilian University of Munich


        Sam is a joint PhD student with the Uhlmann lab. He started in October 2020 to study how sister chromatid cohesion is established during DNA replication.

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        Marta Gross, PhD  🇵🇱


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        PhD in Biochemistry @ Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk

        During her PhD, Marta worked on bacterial DNA replication and its regulation by proteolysis. She joined the lab in 2020 to study budding yeast helicase activation. She is supported by the EMBO Individual Fellowship and Marie Skłodowska-Curie Fellowship.

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        Giselle Chi-ling Lee  🇭🇰

        PhD Student


        BA & MSci in Biochemistry @ University of Cambridge


        Giselle joined the lab in October 2022 to study the mechanisms of chromatin replication. She is funded by the Boehringer Ingelheim Fonds PhD Fellowship.

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        Chew Theng Lim, PhD  🇲🇾 



        PhD in Biochemistry & Molecular Genetics @ Nara Institute of Science and Technology (NAIST)

        Chew Theng studied bacterial Mre11-Rad50 and the behaviour of DNA replication forks on long inverted-repeats during her PhD with Hisaji Maki. She joined the lab in 2018 to study the biochemistry of eukaryotic DNA replication initiation.

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        Toshinari Miyauchi, MD, PhD  🇯🇵



        PhD & MD @ Graduate School of Medicine, Hokkaido University


        Toshinari is a Japanese dermatologist specialising in genetic skin diseases. He has been researching on the “natural gene therapy" phenomenon which could be related to DNA replication. He joined the lab in 2022 to learn more about DNA replication and is currently working on G1-S transition mechanisms.

          Eiko Ozono, PhD  🇯🇵


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          PhD in Medical Science @ Tokyo Medical and Dental University


          After completing postdoctoral positions at Barts Cancer Institute and Babraham Institute, Eiko joined the lab in 2016, and is currently investigating the mechanisms of G1 arrest, more specifically the role of p27Kip1. She is particularly interested in malfunctions that transform normal cells into malignant cells. 

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          Fernando Rosas-Bringas, PhD  🇲🇽



          PhD in Molecular Biology @ University of Groningen


          Fernando joined the lab in September 2022. During his PhD in Dr Michael Chang's lab, he studied the role of Rap1 and G-quadruplexes at budding yeast telomeres. Currently, he is working on chromatin replication.

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          Kang Wei Tan, PhD  🇲🇾



          PhD in Biochemistry & Molecular Genetics @ Nara Institute of Science and Technology (NAIST)

          Kang Wei joined the lab in 2020 to study how stressed DNA replication triggers checkpoint responses. Prior to this, he was a post-doc with Dr Phil Zegerman at the University of Cambridge, where he investigated the role of phosphatase in DNA initiation. 

            Florian Weissmann, PhD  🇩🇪


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            PhD in Biochemistry @ Research Institute of Molecular Pathology (IMP) Vienna

            Florian studied the mechanisms of APC/C activation in mitosis during his PhD with Jan-Michael Peters. He joined the lab in 2018 to study how human DNA replication is initiated and is supported by a Marie Skłodowska-Curie fellowship.

              Jingkun Zeng, PhD  🇨🇳

              PhD Student/Post-doc


              BSc in Biochemistry @ Imperial College London


              Jingkun joined the lab in 2018 to study the mechanism of whole genome duplication in cancer. He is supported by the Boehringer Ingelheim Fonds PhD Fellowship. He finished his PhD in 2023.

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