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We aim to understand how the 46 chromosomes in our cells are precisely duplicated in each cell cycle, how this process responds to DNA damage and how it is misregulated in cancer. To do this, we use a variety of approaches including genetics, cell biology and biochemistry. We have reconstituted chromatin replication with purified proteins, which is providing unprecedented insights into chromosome biology.

Research Areas
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DNA Replication Initiation

How is the MCM replicative helicase loaded and activated in yeast and human cells?


Cell Cycle Control and Cancer

How do altered control mechanisms drive genome instability in cancer?

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Checkpoints at Replication Forks

How are stalled replication forks stabilised by the DNA damage checkpoint pathway?

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Epigenetic Inheritance

How are epigenetic marks inherited during DNA replication?

We are funded by

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